Role of non­coding RNAs in Dengue virus­host interaction

Dengue is potentially a life-threatening arthropod-borne viral infection for which there are no known therapeutic agents till date. Early stage diagnosis of dengue still lacking. Diagnosis only made after severe manifestations and later stages infection. Timely prognosis can prevent related mortalities. The nucleic acid-based therapy has potential to emerge as promising approach early treatment this Many studies have been carried out suggested the regulatory role ncRNAs thereby revealing importance protein-RNA RNA-RNA interactions during Various RNAs either expressed by mammalian cells or generated RNA reported play important roles in life cycle including virus. Thus exploring host-virus interaction will pave novel path understanding pathophysiology febrile dengue. Rapid advances sequencing techniques along with significant developments field therapeutics one approaches antiviral targets. idea based therapies greatly backed Hepatitis C virus drug, Miravirsen successfully completed phase II clinical trial. In present review, we discuss implications different non-coding Differential expression small ncRNA may serve reliable biomarker disease severity also progression.